Urea Cycle Pathway

2. _______ and arginine inhibit argininosuccinase activity.
5. Aspartate reacts with citrulline in cytosol to create _________.
7. _______ leaves the mitochondria and goes to the cytosol; (-) modulated by OTC.
10. Urea cycle location starts in the _______ then moves to cytosol.
13. ________ reacts with citrulline once it has been transported to cytosol.
14. The enzyme that cleaves arginine to form urea and ornithine is __________; requires manganese. (-) mod by Ornithine and urea.
15. Ammonia combines with CO2 or HCO3 to form ____________.
16. The urea cycle occurs in __________ (very specific).
18. ________ is needed for synthesis of carbamoyl PO4 in the mitochondria; Allosteric activator to allow ATP binding; made in liver and intestines.
19. The joining of NH3 and CO2 or HCO3 uses _______.
20. The enzyme to make carbamoyl PO4 is ______ + Mg2+.

1. Removal of ammonia from the body is the ___________.
3. Citrulline converted to argininosuccinate via the enzyme ________ + Mg2+; uses 2 ATP.
4. Carbamoyl-PO4 reacts with ______ in the mitochondria.
6. Total ATP used in the urea cycle is ___________.
8. The urea cycle functions in the______.
9. _________ cleaves argininosuccinate to form fumarate and arginine.
11. ________ and glutamine are the AA that convert to ammonia that starts the Urea cycle.
12. Argininosuccinate synthetase is (-) modulated by argininosuccinate, _______ and AMP.
17. The enzyme responsible for converting carbamoyl-PO4 and ornithine to citrulline is __________.