Vaccinations

1. _______ adjuvants: stimulate TLRs --> enhanced cell-mediated immunity and antibody production
4. a suspension of antigens that is administered to induce immunity
6. T/F Depot adjuvants cause enhanced cytokine production by APCs and have enhanced Th cell responses.
9. _______ vaccines- pros: rapid onset of immunity, sustained immunity after single dose; Cons: potential for reversion to virulence, virulent in immunocompromised, less stable in storage
11. __________ immunization: antigens administered; humoral/cell-mediated responses
12. _______ adjuvants: slow removal of antigen ---> prolonged immune response
15. delay the release of antigens from injection site; induce secretion of chemokines
16. ______ vaccines: ______ of a gene of interest from a pathogen is made and directly delivered; this piece of genetic code is picked up and processed in APC for antigen presentation
17. ________ vaccines: killed whole organism; unable to replicate or induce pathology;

2. ______ vaccines: permits discrimination between a vaccinal and exposure immune response
3. artificial induction of immunity to aid in protection from infectious diseases; active and passive
5. __________ immunization: antibodies administered, sensitize the recipient for a hypersensitive reaction; inhibit the endogenous antibody response of the recipient; temporary protection
7. _______ adjuvants: enhanced antigen presentation --> enhanced cell-mediated immunity and antibody production
8. __________ vaccine: carrier organisms do not cause diseases in vaccinated animals; adjuvant not required
10. ________ vaccines: weakened but intact organism; low-level infection;
13. _________ vaccines: a gene of interest from a pathogen is cloned to a plasmid and delivered directly into the animal; plasmids transfect APC --> pathogen gene is expressed and processed in APC for antigen presentation
14. ______ Vaccines: containing immunological structural proteins or metabolites