Virus Entry

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Across
  1. 3. Influenza virus receptors that can have different sugar linkages depending on species and tissue location
  2. 5. Some viruses require low-pH, because the acid activates ___ that can cleave part of the virus
  3. 8. Only ___ viral glycoprotein conformational changes are reversible
  4. 12. Forms smallish cages during endocytosis
  5. 15. Both MMTV and New World arenaviruses use this receptor
  6. 16. When HIV gp120 binds CD4, ___ changes occur enabling binding to co-receptors
  7. 17. term used to describe fusion proteins that are made with potential energy
  8. 18. __ entry starts when low-pH helps release parts of the viral capsid, popping the endosome. Entry finishes when the capsid is ripped apart at the nuclear pore, releasing the DNA to the nucleus.
Down
  1. 1. Conformation state in which class I fusion proteins form 6-helix bundles
  2. 2. ___ have class II glycoproteins that form parallel dimers on the virion surface
  3. 4. __ are small enough, the entire particle enters the nuclear pore before releasing the DNA
  4. 6. Low-pH induces changes in VP4 forming a pore in the endosome that enables RNA release, enabling __ to infect
  5. 7. Viruses that only require mild low-pH can escape from __ endosomes
  6. 9. Protein cage that helps endocytosis ligands
  7. 10. Protein the helps pinch membrane vesicles off from the plasma membrane
  8. 11. Measles entry starts after the ____ protein binds to receptor, triggering changes in the fusion protein
  9. 13. Viral entry pathway for low-pH dependent entry
  10. 14. __ viral RNPs are the rare RNA virus that enters the nucleus where replication takes place