Across
- 8. First American to be sent into space (1983)
- 9. First to win multiple Grammy awards (1967)
- 10. First American to win an Olympic gold medal- Gold in golf (1900)
- 13. First to receive a US patent (1809)
- 14. First state to grant women the right to vote (1869)
- 16. First female head of a Fortune 20 company (1999)
- 17. First Speaker of the US House of Representatives (2007)
Down
- 1. First inducted into the Rock & Roll Hall of Fame (1987)
- 2. Founder of the American Red Cross (1881)
- 3. First female pilot for a commercial airline in North America
- 4. First to fly solo across the Atlantic Ocean (1928)
- 5. First woman to earn a doctorate degree (1608)
- 6. First to be awarded the Nobel Peace Prize (1931)
- 7. First to summit Mt. Everest (1975)
- 11. First college to admit female students (1837)
- 12. First to graduate dental school (1849)
- 15. First jockey to ride in the Kentucky Derby (1970)