Across
- 4. The central nonribosomal peptide in this paper.
- 5. Module 1 is considered the ___ module.
- 9. This group acted as a click chemistry handle for cross-coupling to a fluorescent molecule.
- 11. The byproduct produced from premature termination of the growing peptide chain.
- 14. Used this tool to determine if tyrocidine analogues were successfully synthesized and what the byproducts were.
- 15. Instead of being linear, tyrocidine A is a ___ peptide.
- 16. What type of biological activity does Tyrocidine A have?
Down
- 1. When reprogramming the A domain, they mutated a Tryptophan residue to ____.
- 2. They used a ___ exchange assay to study the kinetics of the A domain
- 3. Cu(I) catalyzes the cycloaddition of an alkyne and an ____.
- 6. ___ chemistry includes a class of high-yielding reactions that proceed selectively in biological systems without side-reactions
- 7. An enzyme that links building blocks together using energy from ATP.
- 8. Module 4 is considered an ____ module.
- 10. The A-domain activates amino acids through ____.
- 12. ___ chemistry includes a set of reactions that are fast, regiospecific, high yielding, and easy to purify
- 13. This amino acid is sometimes accidentally incorporated instead of the desired Phe analog.