Case 6

3. Basic contractile unit of striated muscle
5. Tumor of the thymus commonly associated with myasthenia gravis
7. First-line drug for Lambert-Eaton syndrome
9. Diagnostic test measuring electrical activity of muscles
10. Neurotransmitter released at the neuromuscular junction
11. Visible muscle twitches seen in lower motor neuron disease
14. Protein that binds calcium to initiate muscle contraction
16. Sarcoplasmic reticulum channel/receptor that releases calcium
18. First-line acetylcholinesterase inhibitor used in MG treatment
20. Enzyme that breaks down acetylcholine in the synaptic cleft
21. Type of lung cancer malignancy most often associated with Lambert-Eaton syndrome
23. G-protein coupled receptor activated by acetylcholine in parasympathetic targets
24. Irreversible acetylcholinesterase inhibitor that can cause cholinergic crisis
25. Drooping eyelid commonly seen in MG

1. Site where motor neuron communicates with skeletal muscle
2. Autoimmune disease with antibodies against nicotinic acetylcholine receptors
4. Autoimmune disorder with antibodies against presynaptic calcium channels
6. Protein linking actin to the extracellular matrix, defective in Duchenne muscular dystrophy
8. Therapy removing circulating antibodies during myasthenic crisis
12. Ligand-gated ion channel activated by acetylcholine at the NMJ
13. Toxin that blocks acetylcholine release causing flaccid paralysis
15. Muscle enzyme elevated in myopathies
17. Antimuscarinic drug used to treat organophosphate poisoning
19. Insulating sheath that speeds nerve conduction
22. Dysfunction such as dry mouth commonly seen in Lambert-Eaton syndrome