Across
- 1. A specialized genomic library of defenses drafted when phosphorylated messengers fly from the JAK signal to the promoter to build internal walls against a virus.
- 5. A measure of the lead actor's maximal performance, which reaches its tragic peak when a cholera toxin jams the alpha subunit's GTPase activity.
- 6. The specific genomic landing strip where a dimerized steroid-receptor complex binds to rewrite the cell's script [Wordlist].
- 7. The elite escort that carries the four-ringed raw material into the mitochondrial furnace to begin the production of life's steroid messengers.
- 9. A single typo in the stable library during the fast read that leaves the JAK partner without its natural USP18 off-switch.
- 11. A vasodilating pain messenger born when biological editors snip the calcitonin script to scream "migraine" to the brain.
- 13. The tissue's lead "paracrine gossip" that uses local channels to tell mitochondria-rich makers to start the stomach’s acid rain.
- 16. A calming, non-packaged traveler that skips the vesicle stage to slip through membranes and modulate the tail of a swimmer.
- 17. The scheduled demolition and regression of the monthly yellow factory when the messenger of pregnancy fails to arrive.
- 18. The gastric laborer that secretes an inactive version of the lead actor, waiting for acid to cut the ribbon on its performance.
- 19. A sensory lie where the "Gate" fails, causing the brain to interpret a gentle, non-noxious greeting as a painful assault.
- 20. A permanent chemical tag added by a comma-shaped visitor to jam a molecular traffic light in the green position, turning Sutherland's second messenger into an intestinal flood.
Down
- 2. The muscle's economical terminator that sweeps the primary cation back into its sarcoplasmic warehouse to end the squeeze.
- 3. The measure of a host's loyalty to the doctor's script, ensuring the drug guest arrives at the target at the right dose and time.
- 4. The thick-filament workhorse that refuses to perform its sliding act until a kinase provides a phosphate power-up in response to a Calcium signal.
- 8. The molecular "off-switch" on a trimeric traffic light; when broken, it allows Adenylyl Cyclase to keep turning ATP into a secondary messenger flood
- 10. The critical journey of a phosphorylated messenger moving the viral war plans from the receptor's shadow into the genomic library.
- 12. The "shoulders to cry on" nervous system that uses short pre-messengers to tell your resistance arteries to tighten the pressure.
- 14. A sideways slide on a dose-response curve defining how little of a blocker is needed to silence a spliced pain message like CGRP.
- 15. The metabolic toll taken by the hepatic gateway during a drug's journey, leaving only a fraction of the survivors to reach the systemic circulation.