Across
- 2. A central cellular respiration pathway, produces NADH and FADH2, occurs in the mitochondria
- 4. The ______ effect; tumor cell reliance on glycolysis rather than oxidation to meet metabolic needs
- 5. By-products of normal oxygen metabolism; can cause irreversible damage to DNA
- 7. any metabolic process that involves the breakdown of complex molecules (such as proteins or lipids) and the release of energy
- 10. Key part of an important TCA cycle intermediate; consists of a β-mercaptoethylamine group linked to the vitamin pantothenic acid (B5) through an amide linkage[3] and 3'-phosphorylated ADP
- 11. term applied to particular biochemical pathways in which metabolites are newly biosynthesized
- 13. abbreviation for an essential metabolite; methyl group donor involved in the methylation of DNA, RNA and histones
- 15. major eukaryotic lipid, named after a legendary mythological creature that creates riddles
- 16. most abundant free amino acid in circulation; very important in cancer metabolism
Down
- 1. serine/threonine kinase; interacts with Akt, a key player in mammalian metabolism
- 3. State of scarcity of a metabolite, like glucose
- 6. Term employed to describe a cellular system used to translocate electrons across impermeable membranes
- 8. endogenous intermediates of metabolism that aberrantly accumulate in cancer cells
- 9. final step of cellular respiration; a series of redox reactions involving the flow of electrons along a series of membrane-bound proteins, coupled with the generation of Adenosine triphosphate (ATP)
- 12. electron donating molecule; used by enzymes to synthesize large biomolecules
- 14. deprivation of oxygen, can drive tumor progression