Across
- 3. - Cellular environment where viruses replicate, making it difficult to target the virus without damaging human tissue
- 4. - The ratio of the dose of a drug that is toxic to humans compared to its minimum effective dose
- 6. - Property describing how easily a drug can be taken by or given to a patient (e.g., oral vs. IV)
- 8. - Desirable drug property where an antimicrobial harms the microbe without damaging host tissues
- 9. - Antimicrobial property that is LOW or POOR when a drug targets structures (like double-stranded DNA or plasma membranes) shared by both pathogen and human host
- 10. - Use of a drug to prevent infection of a person at risk
- 12. - Naturally occurring antimicrobial compounds originally produced as secondary metabolic products of bacteria and fungi
- 15. - All-inclusive term for any antimicrobial drug, regardless of its origin
- 16. - Cell type shared by both humans and fungi, limiting the number of unique drug targets for treatment
- 17. - Bacteriophage-encoded enzymes that degrade the bacterial cell wall peptidoglycan, causing rapid cell lysis and death
Down
- 1. - Bacterial immune system used as a genome editing tool to make targeted cuts in double-stranded DNA resistance genes
- 2. - Viruses that specifically infect and lyse bacterial cells, historically displaced by the advent of antibiotic treatments
- 5. - Ability of a drug to travel through body tissues to reach deep infection site
- 7. - Category of antimicrobial drugs that are isolated from natural biological sources and then chemically modified in the laboratory
- 11. - Reason pharmaceutical companies slow down antibiotic innovation: short treatment courses and low return on investment make them financially non
- 13. - Mechanism by which bacteria survive antimicrobial drugs through active transport pumps, chemical destruction, or modified binding sites
- 14. - Complex, matrix-enclosed community of microbes that relies on quorum sensing to establish and maintain structure