Across
- 3. process by which the affinity of antibodies produced in response to a protein antigen increases with prolonged or repeated exposure to that antigen
- 6. enzyme involved in isotype switching
- 9. immunoglobulin molecule (or BCR type) on a naïve B cell to which an antigen binds
- 12. foci or area where initial T and B cell interactions occur during antigen exposure
- 13. mechanism that leads to affinity maturation
- 15. type of antibody that is generated during parasitic infections
Down
- 1. the region of the follicle containing proliferating B cells
- 2. the molecular mechanism of isotype switching
- 4. nature of antigen that generates antibody response with the help of T cells
- 5. ligand present on T cells that help in proliferation of antigen-specific B cells
- 7. B cells located in the peripheral region of the splenic white pulp (no need to write ‘B cells’)
- 8. B cells that make the bulk of T-dependent, class-switched, and high-affinity antibody responses to protein antigens (no need to write ‘B cells’)
- 10. cells that are activated B cells and most likely are progeny of isotype-switched high-affinity B cells but do not differentiate into active antibody secretors (no need to write the word ‘cells’)
- 11. process by which some B cells differentiate and produce different heavy chain isotypes
- 14. CD4+ T cells that migrate into B cell–rich follicles (abbreviation, no need to write ‘cells’)