Across
- 4. the process by which lymphocyte progenitors in the thymus and bone marrow differentiate into mature lymphocytes
- 6. process because of which each B cell can express an Ig heavy chain from only one of the two inherited parental alleles
- 10. enzymes that remove nucleotides from V, D, and J gene segments at the sites of recombination
- 12. lymphoid-specific enzyme that is essential for the somatic recombination of V and J, or of V, D, and J, gene segments
- 14. receptor responsible for greatest proliferation of developing lymphocytes
- 15. selection facilitating the survival of potentially useful lymphocytes (no need to write the word ‘selection’)
Down
- 1. tolerance that is developed in the generative lymphoid organs (no need to write the word ‘tolerance’)
- 2. hematopoietic stem cells mature into these cells and then these cells give rise to B cells, T cells, and innate lymphoid cells
- 3. name of the process by which developing T or B cells are eliminated if they bind with high affinity to self-antigens.
- 5. transcription factor for T cell maturation (no need to include hyphen)
- 7. t cells that are the least developed progenitors in the thymus
- 8. last name of the scientist who elucidated the mechanism for B- and T-cell receptor diversity
- 9. organ responsible for B-1 cells in a fetus
- 11. events that preserve cells that have produced functional antigen receptor proteins and eliminate potentially dangerous cells (no need to include the word ‘events’)
- 13. gene segment that only occurs in the Ig heavy-chain and TCR β-chain loci