Constipation- Overview

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Across
  1. 2. 17g of this product needs to be mixed with H2O or juice. Also commonly used for bowel prep in colonoscopies
  2. 4. Brand name for naloxegol. MOA: Mu opioid receptor antagonist
  3. 7. Class of pain medications that commonly cause constipation
  4. 8. _____ laxatives form emollient gels that absorb water back into the stool, which push against colon walls to stimulate peristalsis. Gas formation is a common side effect
  5. 9. Constipation is defined by less than _____ bowel movements per week with signs and symptoms
  6. 11. brand name for methylcellulose
  7. 13. Brand name of lubiprostone. MOA: Activates Cl- channels to cause an influx of Na+ into the small intestine, increasing fluid movement into the intestinal lumen
  8. 14. stool softener that is not effective for active constipation
  9. 15. Brand name for Prucalopride. MOA: Activates 5-HT4 receptors which facilitates the release of ACh, resulting in enhanced colonic peristalsis
  10. 18. Poorly absorbed sugar that takes 1-3 days to stimulate a bowel movement (also used to treat hepatic encephalopathy)
  11. 20. poorly absorbed sugar that takes 1-3 days to stimulate a bowel movement
Down
  1. 1. Brand name for psyllium
  2. 3. enteric coated tablets that activate enteric nerves to induce colonic contractions; also comes in 10mg suppositories for quick onset
  3. 5. This class of laxatives include aloe, cascara, and senna. MOA: activates enteric nerves to induce colonic contractions and increases fluid and Na+ secretion into the lumen
  4. 6. recommend slowly increasing _____ into diet over 7-10 days
  5. 10. these types of agents are poorly absorbed sugars that draw water into the colon to stimulate bowel movement
  6. 12. Non-pharmacological recommendations include 6-8 glasses of _____
  7. 16. Brand name methylnaltrexone. MOA: Mu opioid receptor antagonist, stimulates BM within 30 minutes
  8. 17. Brand name for linaclotide. MOA: Guanylate cyclase C agonist that increases chloride and bicarbonate secretions into the intestinal lumen, and inhibits Na+ reabsorption
  9. 19. chronic constipation includes symptoms last more than _____ weeks