Across
- 1. CF can affect bone ___ leading to osteoporosis
- 4. The only anti-inflammatory drug recommended for CF patients
- 5. Pulmonary exacerbations are worsened by ____
- 11. Patients with end-stage lung disease may require a lung ___
- 13. Pathogens are cleared through the mucociliary ___
- 16. There is a hyper-concentration of ___ in the respiratory system
- 21. Neutrophil ___ can be detected early in infants with CF
- 22. Concentrations of this metabolite increase apoptosis and inflammation
- 24. A lack of pancreatic ___ impacts digestion
- 25. Pathogens trigger an _____ response in the lungs
- 28. CF is diagnosed in this age range
- 29. These drugs increase CFTR production
- 30. Inflammation in the CF lung is ___ because it involves many pathways
- 33. CFTR is a transport _____
- 35. The chloride channel opens when it is ___ by protein kinase A
- 36. First corrector drug discovered
- 37. CF related diabetes can be treated with ____
- 39. CF is an autosomal _____ disease
- 40. CF mainly affects this race
- 41. Carriers of the disease are ____
- 42. ___ stress suppresses CFTR function
- 44. Neutrophils produce serine ___ which degrade CFTR
- 45. Stabilizers prevent CFTR ____
- 47. The earliest sign of lung disease in CF patients is ___
Down
- 2. These factors are responsible for upregulating the airway inflammatory response in CF patients
- 3. CF can cause mortality due to failure of this system
- 6. Cells impacted in the respiratory, GI, and reproductive tracts
- 7. The most common respiratory pathogen in CF patients is staphylococcus ___
- 8. Substance responsible for expansion and solubilization of mucin
- 9. Effect of CF on reproductive system
- 10. Increased sweating may result in ____
- 12. In CF patients, the airway surface is more __ than normal
- 14. The ion channel is ____ dependent
- 15. Kinds of cells which secrete mucus
- 17. This amino acid is deleted in mutated genes
- 18. Type of glands impacted
- 19. This type of immune cell is recruited first during inflammation
- 20. Neonatal screenings of the disease look at levels of serum ____
- 23. Forced expiratory ___ detects disease progression
- 26. This acid is highly expressed in the cell membranes of CF patients
- 27. Some drugs used to treat CF are CYP3A ___
- 28. These kinds of channels are not expressed properly
- 30. In Class II CFTR mutations, the protein is ____
- 31. Elevated __ levels in sweat are used as a diagnostic indicator
- 32. Process which take place in the distal tubules of sweat glands
- 34. CFTR deficiency affects ___ pressure
- 38. Mucins are packaged as ___
- 43. A rare complication of CF is chronic ____
- 45. CF patients have glutathione ___ which can lead to inflammation
- 46. The use of ___ saline helps a CF patient to expectorate