Across
- 2. antibody that defends against parasites and causes anaphylactic shock
- 4. cells/These cells are known to function as the "brains" of the immune system
- 7. cells have the ability to _______ when activated
- 10. cells that have never been activated by encountering their cognate antigen
- 14. switching/B cell changes the class of antibody it produces
- 17. cellular protein that catalyzes the release of CLIP and allows an exogenous protein to be loaded into the groove of the class II MHC molecule
- 19. chippers that cut up proteins into peptides
- 20. helper T cells that remain "unbiased" when they are first activated
- 21. transporter proteins involved in MHC molecule presentation
- 24. tiny region of the cognate antigen that a B cell receptor actually binds to is called its _______
- 25. factor that stimulates the proliferation of helper T cells, and growth factor for B cells
Down
- 1. selection/the process of testing T cells for MHC restriction- "Do you have receptors on that recognize one of the self MHC molecules which I am expressing on my surface?"
- 3. order of choice of gene segments by recombination
- 5. T cells generally express the _____ co-receptor
- 6. produced by helper T cells that "recharges" NK cells
- 8. selection/referred to as the second test to test for tolerance of self
- 9. many BCRs are brought close together on the B cell surface; this is needed to generate an activation signal
- 11. main antibody class that guards the mucosal surfaces of the body
- 12. main antibody produced when a virgin B cell gets first activated
- 13. that encourages B cells to produce IgA antibodies
- 15. hypermutation/The rearranged genes for the BCR can mutate to increase the affinity of the BCRs for their cognate antigen
- 16. eating"
- 18. positive/T cells that express both CD4 and CD8 co-receptor molecules
- 22. chain/This molecule sits in the groove of the MHC II molecule and keeps it from picking up other peptides in the endoplasmic reticulum
- 23. T cells generally express the _____ co-receptor