Across
- 4. Binding one O2 increases affinity for next (13)
- 5. Binds deoxy-Hb, reduces O2 affinity (3)
- 6. CO2 and H+ facilitate O2 displacement from Hb (7)
- 8. Low oxygen affinity state, stabilized by salt bridges (5)
- 10. Moves into RBC to maintain electrical neutrality (8)
Down
- 1. Catalyzes CO2 hydration in RBCs (17)
- 2. CO2 bound to Hb globin chains (9)
- 3. O2 dissociation curve shifts during exercise/fever (5)
- 7. Buffers H+ ions in Hb (9)
- 9. Oxygenation of Hb promotes CO2 dissociation (4)