Across
- 3. IL; general designation for different cytokines & chemical messengers secreted by immune cells
- 5. Human leukocyte antigen; name of MHC gene complex and proteins in humans
- 8. T-cell receptor; the antigen receptor on T-cells
- 9. Ag; a molecule recognized by Ab or BCR and is presented by MHC molecules to TCRs
- 12. leukocytes PMN; WBCs with multi-lobed nuclei and cytoplasmic granules
- 14. Tumor necrosis factor; a cytokine produced by macrophages and T-cells that is highly pro-inflammatory
- 16. Pathogen associated molecular patterns; repeated molecular patterns on microbes
- 18. T-lymphocytes CTL; CD8+ T-cells with the function of targeting and killing virally infected cells by apoptosis
- 19. Cluster of differentiation; cell-surface molecules on immune cells that help differentiate one immune cell from another
- 20. C-reactive protein
- 21. Major histocompatibility complex; Family of cell surface molecules that present antigens to T-cells
- 24. Human immunodeficiency virus
- 25. Ab; Immunoglobulin secreted by plasma cells
- 26. Recognize PAMPs on pathogens and help initiate immune response
- 27. End stage of disease in HIV infection
Down
- 1. Pattern recognition receptors; receptors on immune cells that bind to PAMPs on microbes
- 2. LPS; a cell wall component of gram negative bacteria which can be bound by TLR-4 on macrophages and dendritic cells
- 3. Ig; protein family to which antibodies and b-cell receptors belong
- 4. Subset of CD4+ T-cells that produce cytokines to stimulate B-cells to produce antibodies
- 5. Highly active anti-retroviral therapy; a multiple drug therapy treatment for HIV infection
- 6. surface immunoglobulin; an immunoglobulin expressed on B-cell surface
- 7. Thymus derived lymphocyte comprised of two subsets: CD4 T-cells and CD8 T-cells
- 10. Cell-mediated immunity; adaptive immune responses mainly due to effector T-cells
- 11. Regulatory CD4+ T-cells responsible for suppressing immune responses
- 13. Natural killer cell; large granular lymphocyte that induce apoptosis of compromised cell
- 15. Presents antigen via MHC molecules to T-cell receptors
- 17. Membrane attack complex; end product of the Complement cascade that kills pathogens directly by forming a pore in pathogen membrane leading to lysis
- 18. Cell adhesion molecule
- 22. Member of TNF receptor family expressed on certain cells allowing for them to be killed by cells expressing Fas ligand
- 23. T-cell that express co-receptor protein CD4, which plays a role in adaptive immunity
- 27. Antibody dependent cellular cytotoxicity; mechanism by which NK cells induce apoptosis