Across
- 1. A family name for cytokines that help cells combat vital infections
- 3. Ag receptor on T cells
- 4. Cells A subset of CD4+ cells that are characterized by the cytokines that they produce including IFN gamma involves in activating macrophages and IL-2 involved in promoting CTL responses against intracellular pathogens
- 5. Soluble acute phase response to a protein that can bind mannose on pathogens, activate the lectin pathway of complement and acts as a opsonin
- 6. A large granular lymphocyte that plays the role of a innate effector cell by causing apoptosis of target cells
- 7. The end product of the complement cascade that can kill pathogens directly by forming a pore in the pathogen membrane leading to lysis
- 9. Immunoglobulin secreted by plasma cells
- 10. Cell adhesion molecule
- 11. White blood cells with multi-lobed nuclei and cytoplasmic granules
- 14. subset of CD4+ T cells characterized by the cytokines they produce, including IFN- gamma involved in fully activating macrophages, and IL-2 involved in promoting CTL responses against intracellular pathogens
- 18. Amino acid sequence in cytoplasmic domains of membrane receptors involves in signal transduction
- 20. A T cell subset that is in charge of suppressing a immune response
- 23. A cell wall component of gram negative bacteria which can be bound by TLR-4 on macrophages and dendritic cells
- 24. Receptors on immune cells and epithelial cells that recognize and bind to PAMPS on microbes
- 26. Protein family that antibodies and B-cell receptors belong to
Down
- 1. A immune response
- 2. Transcription factor that helps to activate the expression of many pro-inflammatory genes
- 3. Thymus derived lymphocyte that is comprised of CD4T and CD8 T cells
- 4. A cytokine produced by macrophages and T cells that are highly pro inflammatory
- 6. A key transcription factor that is required to bind to the IL-2 promoter to cause IL-2 transcription
- 8. Repeating molecular patterns on microbes that are recognized by PRRs on immune cells
- 12. Designation for a family of surface cell molecules involved in the expression of peptide antigens to T cells
- 13. General designation of many of the different cytokines, chemical messengers that are secreted by immune cells that help in their communication with other cells
- 15. Name of MHC gene complex and proteins in humans
- 16. Autoimmune disease where autoantibodies form immune complexes
- 17. Human immunodeficiency virus
- 19. A immunoglobulin that is on the surface of B cells
- 21. Short DNA sequences flanking Ig and TCR V,D and J gene segments that serve as the binding sites for the RAG complex, allowing Ig and TCR gene rearrangement
- 22. A group of pattern recognition receptors that are present on many leukocytes and epithelial cells that recognize PAMPS on pathogens and help initiate immune responses
- 25. The two genes essential for Ig and TCR gene rearrangement, their gene products comprise the RAG complex