Across
- 1. the regions of the antigen binding loops of Ig molecules, antibodies and Tcell receptors that come into contact with antigen
- 3. repeating molecular patterns on microbes that are recognized by PRRs on immune cells
- 4. designation for a family of cell surface molecules involved in the presentation of peptide antigens to Tcells
- 6. a transcription factor that causes several hundred tissue-specific genes to be transcribed by a subpopulation of epithelial cells in the thymus
- 7. adaptive immune respones in which there is a major role for effector Tcells
- 9. amino acid sequence in cytoplasmic domains of membrane receptors involved in signal transduction
- 13. a cytokine produced by macrophages and Tcells that is highly pro-inflammatory
- 16. end product of complement cascade that can kill pathogens directly by forming a pore in pathogen membrane leading to lysis
- 17. transcription factor expressed in Treg cells that is needed for Treg cell function
- 20. large granular lymphocyte that serves as an innate effector cell by inducing apoptosis of targeted infected cells or of cancer cells
- 22. short DNA sequences flanking Ig and TCR V, D & J gene segments that serve as the binding sites for the RAG complex, allowing Ig and TCR gene rearrangement
- 24. the Ag receptor on Tcells
- 25. lymphocyte that upon activation can differentiate into plasma cells secreting antibody molecules of memory cells
Down
- 1. acute phase protein that binds to phosphocholine, a constituent of certain bacteria, that can trigger complement activation and acts as an opsonin
- 2. A cell that is able to present antigen via MHC molecules to Tcell receptors on Tcells
- 5. multiple drug treatment for HIV infection
- 8. family name for cytokines that help resist viral infections
- 9. Cells surface ligands for the leukocyte integrins; critical in binding of lymphocytes and other leukocytes to certain cells
- 10. a mechanism NK cells use to induce apoptosis in virally infected or tumor cells
- 11. an immunoglobulin that is expressed on Bcell surfaces
- 12. general designation of many of the different cytokines, chemical messengers secreted by immune cells that help their communication with other cells
- 13. thymus derived lymphocyte that are comprised of 2 different subsets CD4 & CD8
- 14. member of TNF receptor family expressed on certain cells that make them susceptible to being killed by cells expressing this ligand
- 15. receptors on immune cells and epithelial cells that recognize and bind to PAMPs on microbes
- 17. part of an antibody responsible for antigen binding
- 18. white blood cells with multi-lobed nuclei and cytoplasmic granules
- 19. a type of APC that presents antigens in the context of MHC to Tcells
- 21. a cell wall component of gram negative bacteria which can be bound by TLR4 on macrophages and dendritic cells
- 23. autoimmune disease where autoantibodies (against DNA, RNA & proteins associated with nucleic acids) form immune complexes
- 24. a family of PRR present on many leukocytes and epithelial cells that recognize PAMPs on pathogens and help initiate immune response
- 26. designation for specific cell-surface molecules on immune cells that help differentiate one immune cell from another