Across
- 2. CD8+ T cells with the effector function of targeting and killing virally infected cells and tumor cells by apoptosis
- 4. general designation of many of the different cytokines which are chemical messengers secreted by immune cells that help in their communication with other cells
- 7. white blood cells with multi-lobed nuclei and cytoplasmic granules
- 8. immunoglobulin secreted by plasma cells
- 11. cells surface ligands for the leukocyte integrins; Critical in binding of lymphocytes and other leukocytes to certain cells
- 12. the regions of the antigen binding loops of Ig molecules, antibodies and T cell receptors that come into contact with antigen
- 14. a family of Pattern Recognition Receptors present on many leukocytes and epithelial cells that recognize PAMPs on pathogens and help initiate immune responses
- 15. a cell that is able to present antigen via MHC molecules to T cell receptors on T cells
- 16. amino acid sequence in cytoplasmic domains of membrane receptors involved in signal transduction
- 18. short DNA sequences flanking Ig and TCR V D and J gene segments that serve as the binding sites for the RAG complex allowing Ig and TCR gene rearrangement
- 20. a molecule that is recognized in native (original) structure by antibodies or B cell receptor, or a peptide that is presented by MHC molecules to T cell receptor
- 21. designation for specific cell-surface molecules on immune cells that help to differentiate one immune cell from another
- 22. a type of APC that presents antigen in the context of MHC to T cells
- 23. acute phase protein that binds to phosphocholine that can trigger Complement activation and acts as an opsonin
- 25. end product of the Complement cascade that can kill pathogens directly by forming a pore in pathogen membrane leading to lysis
- 26. Fragment with antigen binding: the part of an antibody (that can be isolated by protease digestion) responsible for antigen binding consisting of the light chain and amino-terminal half of the heavy chain disulfide-bonded together
Down
- 1. autoimmune disease where autoantibodies (against DNA, RNA, and proteins associated with nucleic acids) form immune complexes
- 2. adaptive immune responses in which there is a major role for effector T cells
- 3. name of MHC gene complex and proteins in humans
- 5. a cell wall component of gram negative bacteria which can be bound by TLR-4 on macrophages and dendritic cells
- 6. multiple drug treatment for HIV infection
- 9. sIg on B cells that binds Ag and transmits signal 1 to activate B cells.
- 10. receptors on immune cells and epithelial cells that recognize and bind to PAMPs on microbes
- 11. family name for cytokines that help cells to resist viral infections
- 13. Member of TNF receptor family expressed on certain cells that makes them susceptible to being killed by cells expressing the specific ligand
- 14. the Ag receptor on T cells
- 16. protein family to which antibodies and B-cell receptors belong
- 17. designation for a family of cell surface molecules involved in the presentation of peptide antigens to T cells
- 19. an immunoglobulin that is expressed on B cell surface
- 20. a mechanism NK cells use to induce apoptosis in virally infected cells or tumor cells
- 24. repeating molecular patterns on microbes that are recognized by PRRs on immune cells
- 25. soluble acute phase response protein that can bind mannose on pathogens; can activate the lectin pathway of Complement and acts as an opsonin