Across
- 6. Cells that display MHC molecules to T-cells. Job is to activate T-cells (2 words)
- 9. When BCRs are clustered together to generate an activation signal they are ______
- 10. The signal supplied from a helper T-cell to activate a B-cell. From MHC molecules
- 12. Type of proteins found inside the cell. Cellular proteins, enzymes, structural proteins, etc.
- 18. Area in the thymus where negative selection takes place
- 19. B-cells that have never been activated by their cognate antigen (starts with v)
- 25. Different gene segments getting pasted together to create the heavy chain
- 26. Enzymes responsible for destroying proteins and cutting them up into peptides
- 27. A bean-shaped organ that are like "dating bars" for immune system cells (2 words, singular)
- 29. The process of programmed cell death. "Cell commits suicide"
- 31. Type of cytokine that tells immune cells where to go and when to go (e.g. CXCL13)
- 33. Are mucosal-associated lymphoid tissues that line the intestines. Sample antigens from the intestine through M cells (2 words)
- 35. The hypothesis immunologists favor for how a T-cell survives both positive and negative selection
- 38. Type of cell that T-cells are after they have become activated and are ready to work
- 40. Chain that sits in the groove of class 2 MHC molecules to keep it from picking up peptides in the ER
- 41. Type of rearrangement that creates a full length Heavy chain protein
- 42. An active lymphoid follicle, where B-cells proliferate and become "fragile" (2 words)
Down
- 1. Type of selection of testing T-cells for MHC restriction
- 2. Type of B-cells that come in contact with blood when it enters the spleen. Can respond quickly and don't need T-cell help to become activated (2 words)
- 3. All secondary lymphoid organs have these. They are islands of follicular dendritic cells within a sea of B-cells (2 words)
- 4. B-cells that have never been activated by their cognate antigen (starts with n)
- 5. Virgin T-cells are _____ when they recognize their cognate antigen but doesn't receive the co-stimulation to become activated
- 7. Type of regulatory T-cell that is generated in the thymus and can suppress the activation of potentially self-reactive T-cells
- 8. Type of selection in the thymus that tests for tolerance of self
- 11. Type of T-cell activation, when virgin B-cells don't need the help of T-cells to become activated
- 13. Type of epithelial cells in the cortex of the thymus that do the testing for positive selection (2 words)
- 14. Type of "unnatural" B-cell activation where activation does not depend on the cognate antigen, but depends on a mitogen
- 15. The antigen that a BCR or TCR will recognize
- 16. Type of cell that is the "coach" of the immune system team
- 17. Type of B-cell that becomes an antibody factory
- 20. Organ where T-cells first learn tolerance of self
- 21. What happens when cTEC's capture their own intracellular proteins
- 22. Type of T-cell activation, when virgin B-cells need the help of T-cells to become activated
- 23. Type of fully mature Th cell that can rescue fragile germinal center B-cells
- 24. When a B-cell changes the class of antibody it produces
- 28. Small protein fragments
- 30. Type of B-cell that recalls the first exposure to an antigen and helps defend against subsequent exposures
- 32. Organ that functions as a blood filter.
- 34. B-cells that have been activated by their cognate antigen
- 36. Proteins that are found outside of the cell
- 37. Type of proteins that help "decommission" T-cells as the battle winds down (e.g. CTLA-4 and PD-1)
- 39. Region of the antigen that the BCR or TCR will bind to