Across
- 2. Regulatory T cell that protects from autoimmune disease
- 8. T cell that generally expresses the CD4 co-receptor (3 words - no abbreviations)
- 10. Antigen presenting cell that can "re-stimulate" experienced T cells, can be activated by IFN-g and DOESN'T travel to the lymph nodes (2 words)
- 13. Antibody that is highly effective at neutralizing viruses and fixing complement
- 14. These cut proteins into peptides in the cytoplasm
- 17. This helper T cell subset produces IL-17 and IL-21, and is activated by IL-6 and TGFb
- 18. This helper T cell subset produces IL-4, IL-5, and IL-13 and is activated by IL-4
- 19. The step of B cell maturation in which the rearranged genes can mutate to increase the average affinity of BCRs for their cognate antigen (2 words)
- 21. These cells are embedded in the regions of the secondary lymphoid organs, with the primary function of displaying antigen to B cells (3 words)
- 25. The step of B cell maturation in which the B cell changes the class of antibody it produces (2 words)
- 26. Region of the cognate antigen that a BCR actually binds to
- 28. Regulatory T cell that dampens the immune response (abbreviation)
- 30. A B cell that is an "antibody factory"
- 31. Combination of gene segments that will produce a full-length Hc protein (2 words)
Down
- 1. Fragments of proteins manufactured by the cell; displayed by class I MHC molecules (2 words)
- 3. T cell that generally expresses the CD8 co-receptor (3 words - no abbreviations)
- 4. Fully mature Th cells that help B cells switch classes or undergo somatic hypermution through the interaction between CD40L and CD40 proteins(4 words)
- 5. Antigen presenting cell that can activate virgin T cells; these cells can be activated by TNF and travel to lymph nodes to present antigen (2 words)
- 6. Protein that can bind to cell membranes and drill holes in them
- 7. Antibody that guards the mucosal surfaces of the body
- 9. Antigens that come from outside the cell; displayed by class II MHC molecules (2 words)
- 11. "Doorway" through which B and T cells enter the secondary lymphoid organs from the blood (3 words, abbreviation)
- 12. B cells that have encountered their cognate antigen and have been activated (3 words)
- 15. Antigen presenting cell that is not used during initial stages of infection, but can quickly activate helper T cells by concentrating antigen for presentation
- 16. Antibody that activates the classical (antibody-dependent) pathway; first antibody made by B cells
- 20. Antibody that causes allergies and anaphylactic shock
- 22. This helper T cell subset produces TNF, IFN-g, and IL-2 and is activated by IL-12
- 23. Protein that prevents the class II MHC molecule from picking up other peptides in the ER AND guides class II MHC molecules through the Golgi apparatus (2 words)
- 24. These transporter proteins carry proteasomes across the membrane of the endoplasmic reticulum
- 27. This helper T cell subset is unbiased and commits to a subset based on the cytokine environment
- 29. Enzyme that triggers cells to commit suicide by apoptosis once it enters the cytoplasm of the target cell (2 words)