Across
- 1. receptor, the Ag receptor on T cells
- 4. Member of TNF receptor family expressed on certain cells that makes them
- 5. a peptide that is presented by MHC molecules to T cell receptor
- 8. Transcription factor expressed in Treg cells that is needed for Treg cell function
- 10. receptor, a family of Pattern Recognition Receptors present on many leukocytes and epithelial cells that recognize PAMPs on pathogens and help initiate immune responses
- 11. recognition receptors, receptors on immune cells and epithelial cells that recognize and bind to PAMPs on microbes
- 12. immunoglobulin secreted by plasma cells
- 13. the regions of the antigen binding loops of Ig molecules, antibodies and T cell receptors that come into contact with antigen
- 15. T cells that express the co-receptor protein CD8 which upon activation differentiate into cytotoxic T lymphocytes (CTLs)
- 16. cell, a type of APC that presents antigen in the context of MHC to T cells
- 17. adhesion molecules, cells surface ligands for the leukocyte integrins; Critical in binding of lymphocytes and other leukocytes to certain cells
- 19. acute phase protein that binds to phosphocholine that can trigger Complement activation and acts as an opsonin
- 21. Human immunodeficiency virus
- 23. leukocyte antigen, name of MHC gene complex and proteins in humans
- 24. a molecule that is recognized in native (original) structure by antibodies or
- 26. a cytokine produced by macrophages and T cells that is highly pro-inflammatory
- 27. to being killed by cells expressing the Fas ligand
- 30. leukocytes, white blood cells with multi-lobed nuclei and cytoplasmic granules
Down
- 2. a cell wall component of gram negative bacteria which can be bound by TLR-4 on macrophages and dendritic cells
- 3. transcription factor that helps activate the expression of many pro-inflammatory genes
- 6. T cells which upon activation differentiate into distinct Thelper phenotypes with different roles in adaptive immunity
- 7. CD8+ T cells with the effector function of targeting and killing virally infected cells and tumor cells by apoptosis
- 9. attack complex, end product of the Complement cascade that can kill pathogens directly by forming a pore in pathogen membrane leading to lysis
- 14. general designation of many of the different cytokines, chemical messengers secreted by immune cells that help in their communication with other cells
- 18. a cell that is able to present antigen via MHC molecules to T cell receptors on T cells
- 20. protein family to which antibodies and B-cell receptors belong
- 22. family name for cytokines that help cells to resist viral infections; type 1 include IFN-alpha and IFN-beta, as distinguished from IFN-gamma.
- 25. a transcription factor that causes several hundred tissue-specific genes to be transcribed by a subpopulation of epithelial cells in the thymus
- 28. a lymphocyte that upon activation can differentiate into plasma cells secreting antibody molecules or memory cells
- 29. killer cell, large granular lymphocyte that serves as an innate effector cell by inducing apoptosis of target cells (virally infected cells or tumor cells)
- 31. histocompatibility complex, designation for a family of cell surface molecules involved in the presentation of peptide antigens to T cells
- 32. Cell adhesion molecule