Across
- 3. molecule that is recognized in native structure by antibodies or B cell receptor, or a peptide that is presented by MHC molecules to T cell receptor
- 4. large mononuclear phagocyte that takes residence in many different tissues and organs, and contributes to innate immune resposnses
- 6. protein family to which antibodies and B cell receptors belong
- 7. multiple drug treatment for HIV infection
- 8. cell surface ligands for the leukocyte integrins
- 9. a type of cell that is able to present antigen via MHC molecules to T cell receptors on T cells
- 11. transcription factor expressed in Treg cells that is needed for T reg cell function
- 12. immunoglobulin secreted by plasma cells
- 15. large granular lymphocyte that serves as an innate effector cell by inducing apoptosis of target cells
- 18. type of adaptive immunity in which there is a major role for effector T cells
- 20. end product of the complement cascade that can kill pathogens directly by forming a pore in pathogen membrane leading to lysis
- 25. the antigen receptor on T cells
- 26. subset of CD4+ T cells that are involved in fully activating macrophages and promoting CTL responses against intracellular pathogens
- 27. cell wall component of gram negative bacteria which can be bound by TLR-4 on macrophages and dendritic cells
- 28. a transcription factor that causes several hundred tissue-specific genes to be transcribed by a subpopulation of epithelial cells in the thymus
- 30. a type of immunoglobulin that is expressed on B cell surface
Down
- 1. pathogen associated molecular patterns
- 2. type of APC that presents antigen in the context of MHC to T cells
- 5. type of leukocyte with multi-lobed nuclei and cytoplasmic granules
- 9. acquired immune deficiency syndrome: the end stage of disease in HIV infection
- 10. cell adhesion molecule
- 13. type of pattern recognition receptors present of leukocytes and epithelial cells that recognize PAMP's on pathogens
- 14. acute phase protein that binds to phosphocholine, and can trigger complement activation, and acts as an opsonin
- 16. family name for cytokines that helps cells to resist viral infections
- 17. general designation of many of the different cytokines
- 18. type of CD8+ T lymphocyte with the effector function of targeting and killing virally infected cells and tumor cells via apoptosis
- 19. thymus-derived lymphocyte that are comprimised of two different subsets (CD4 and CD8)
- 21. soluble acute phase response protein that can bind mannose on pathogens and can activate the lectin pathway of Complement
- 22. a mechanism NK cells use to induce apoptosis in virally infected cells or tumor cells
- 23. receptors on immune cells and epithelial cells that recognize and bind to PAMP's on microbes
- 24. subset of CD4+ T cells that are involved in stimulating B cells to produce antibody against extracellular pathogens
- 29. B lymphocyte that upon activation can differentiate into plasma cells secreting antibody molecules or B memory cells