Across
- 4. Acute phase protein that binds to phosphocholine, a constituent of certain bacteria, can trigger complement activation and acts as an opsonin
- 5. Large mononuclear phagocyte that takes residence in many different tissues and organs and contributes to innate immune responses and can act as an effector cell in adaptive immune responses
- 6. Repeating molecular patterns on microbes that are recognized by PRRs on immune cells
- 8. Cells surface ligands for the leukocyte integrins; critical in binding of lymphocytes and other leukocytes to certain cells
- 9. Large granular lymphocyte that serves as an innate effector cell by inducing apoptosis of target cells
- 12. A mechanism NK cells use to induce apoptosis in virally infected cells or tumor cells
- 13. General designation of many of the different cytokines
- 15. Amino acid sequence in cytoplasmic domains of membrane receptors involved in signal transduction (tyrosine-based)
- 16. Family name for cytokines that help cells to resist viral infections
- 17. Member of TNF receptor family expressed on certain cells that makes them susceptible to being killed by cells expressing its ligand
- 18. A type of APC that presents antigen in the context of MHC to T cells
- 21. Regulatory CD4+ T cells, a T cell subset that is responsible for suppressing or limiting immune responses
- 23. Characteristic of leukocytes; WBCs with multi-lobed nuclei and cytoplasmic granules
- 24. Immunoglobulin secreted by plasma cells
Down
- 1. The part of antibody that consists of the carboxy terminal halves of the two heavy chains disulfide-bonded to each other
- 2. A cell wall component of gram negative bacteria which can be bound by TLR-4 on macrophages and dendritic cells
- 3. Name of MHC gene complex and proteins in humans
- 7. A transcription factor that causes several hundred tissue-specific genes to be transcribed by a subpopulation of epithelial cells in the thymus
- 10. Cytokine produced by effector CD4+ T cells, CD8+ T cells, NK cells; primary actions are to act with IL-12 to induce TH1 differentiation & to fully activate macrophages
- 11. Family name for chemokines, chemicals that are a sub-class of cytokines with cell-attractant properties
- 12. A molecule that is recognized in native (original) structure by antibodies or B cell receptors, or a peptide that is presented by MHC molecules to T cell receptor
- 14. A family of pattern recognition receptors present on many leukocytes and epithelial cells that recognize PAMPs on pathogens and help initiate immune responses
- 19. Cytokine produced by macrophages and T cells that is highly pro-inflammatory
- 20. Lymphocyte that upon activation can differentiate into plasma cells secreting antibody molecules or respective memory cells
- 22. Highly active anti-retroviral therapy: multiple drug treatment for HIV infection