Across
- 6. slg on B cells that binds Ag and transmits signal 1 to activate B cells
- 9. chemical messengers secreted by immune cells that help in their communication with other cells
- 11. abbreviation for name of MHC gene complex and proteins in humans
- 15. family of pattern recognition receptors present on leukocytes and epithelial cells that recognize PAMPs on pathogens and help initiate immune response
- 16. abbreviation for a cell that is able to present antigen via MHC molecules to T cell receptors on T cells
- 17. one of two recombination activating genes which are essential for Ig and TCR gene rearrangement
- 18. family name for cytokines that help cells to resist viral infections
- 19. T cells that express the co-receptor protein which upon activation differentiate into cytotoxic T lymphocytes
- 20. immunoglobulin secreted by plasma cells
- 21. protein family to which antibodies and B-cell receptors belong
- 22. abbreviation for the Ag receptor on T cells
- 23. abbreviation for cell adhesion molecule
- 24. an abbreviation for a mechanism NK cells use to induce apoptosis in virally infected cells or tumor cells
- 25. abbreviation for the designation of a family of cell surface molecules involved in presentation of peptide antigens to T cells
- 26. family name of chemokines, chemicals that are a sub-class of cytokines with cell-attractant properties
- 28. thymus-derived lymphocytes that are comprise of two different subsets, CD4 T cells and CD8 T cells
- 29. large granular lymphocyte that serves as innate effector cell by inducing apoptosis of virally infected cells and tumor cells
Down
- 1. large mononuclear phagocyte that contributes to innate immune responses; can act as effector cell in adaptive immune responses
- 2. B lymphocyte that upon activation can differentiate into plasma cells secreting antibody molecules or B memory cells
- 3. an immunoglobulin that is expressed on B cell surface
- 4. abbreviation for a transcription factor that causes several hundred tissue-specific genes to be transcribed by a subpopulation of epithelial cells in the thymus
- 5. abbreviation for white blood cells with multi-lobed nuclei and cytoplasmic granules
- 7. T cells that express the co-receptor protein which upon activation differentiate into distinct T-helper phenotypes
- 8. cell wall component of gram negative bacteria which can be bound by TLR-4 on macrophages and dendritic cells
- 10. transcription factor that helps activate the expression of many pro-inflammatory genes
- 12. type of APC that presents antigen in the context of MHC to T cells
- 13. abbreviation for receptors on immune cells and epithelial cells that recognize and bind to PAMPs on microbes
- 14. abbreviation for an autoimmune disease where autoantibodies form immune complexes
- 15. regulatory CD4+ T cells: a T cell subset that is responsible for suppressing or limiting immune responses
- 27. recognized in native structure by antibodies or B cell receptor; a peptide that is presented by MHC molecules to T cell receptor