Across
- 1. Cell adhesion molecule
- 6. family name for cytokines that help cells to resist viral infections; type 1 interferons include IFN-alpha and IFN-beta, as distinguished from IFN-gamma.
- 8. Human immunodeficiency virus
- 9. Systemic lupus erythematosus: autoimmune disease where autoantibodies (against DNA, RNA, and proteins associated with nucleic acids) form immune complexes
- 12. tumor necrosis factor-alpha: a cytokine produced by macrophages and T cells that is highly pro-inflammatory
- 16. large mononuclear phagocyte that takes residence in many different tissues and organs and contributes to innate immune responses and can act as an effector cell in adaptive immune responses
- 19. Immunoreceptor tyrosine-based activation motifs: amino acid sequence in cytoplasmic domains of membrane receptors involved in signal transduction
- 21. a cell wall component of gram negative bacteria which can be bound by TLR-4 on macrophages and dendritic cells
- 23. Subset of CD4+ T cells characterized by the cytokines they produce, including IFN-gamma involved in fully activating macrophages, and IL-2 involved in promoting CTL responses against intracellular pathogens
- 25. Surface immunoglobulin: an immunoglobulin that is expressed on B cell surface
Down
- 2. Autoimmune regulator: a transcription factor that causes several hundred tissue-specific genes to be transcribed by a subpopulation of epithelial cells in the thymus
- 3. Toll-like receptor: a family of Pattern Recognition Receptors present on many leukocytes and epithelial cells that recognize PAMPs on pathogens and help initiate immune responses
- 4. immunoglobulin secreted by plasma cells
- 5. general designation of many of the different cytokines, chemical messengers secreted by immune cells that help in their communication with other cells
- 7. Recombination signal sequences: short DNA sequences flanking Ig and TCR V, D and J gene segments that serve as the binding sites for the RAG complex, allowing Ig and TCR gene rearrangement (somatic recombination)
- 10. thymus-derived lymphocyte that are comprised of two different subsets, CD4 T cells and CD8 T cells
- 11. a molecule that is recognized in native (original) structure by antibodies or B cell receptor, or a peptide that is presented by MHC molecules to T cell receptor
- 13. Cell mediated immunity: adaptive immune responses in which there is a major role for effector T cells
- 14. Transcription factor expressed in Treg cells that is needed for Treg cell function
- 15. protein family to which antibodies and B-cell receptors belong
- 17. Family names of chemokines, chemicals that are a sub-class of cytokines with cell-attractant properties
- 18. Pathogen associated molecular patterns: repeating molecular patterns on microbes that are recognized by PRRs on immune cells
- 20. Highly active anti-retroviral therapy: multiple drug treatment for HIV infection
- 22. Cluster of differentiation: designation for specific cell-surface molecules on immune cells that help to differentiate one immune cell from another
- 24. Complementarity determining regions: the regions of the antigen binding loops of Ig molecules, antibodies and T cell receptors that come into contact with antigen