medicinal chemistry

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Across
  1. 2. Another term for adrenergic antagonist; blocks effects of sympathetic neurotransmitters.
  2. 5. A compound that binds to a receptor but does not activate it, blocking the effect of an agonist.
  3. 7. The fraction of an administered dose that reaches the systemic circulation in active form.
  4. 9. Chemical groups with similar physical or chemical properties that produce similar biological effects.
  5. 11. Inactive compounds that become active after metabolic conversion inside the body.
  6. 12. Peptide involved in vasoconstriction and blood pressure regulation.
  7. 14. The study of how the body absorbs, distributes, metabolizes, and excretes drugs.
  8. 17. Widening of blood vessels resulting from relaxation of smooth muscle in vessel walls, leading to increased blood flow and reduced blood pressure.
  9. 19. The process by which drugs move from the bloodstream to tissues and organs.
  10. 20. Include hydrogen bonds, ionic bonds, Van der Waals, and hydrophobic interactions that stabilize drug–target binding.
  11. 21. The biochemical modification of drugs, mainly in the liver, to facilitate excretion.
Down
  1. 1. Drugs that mimic the action of acetylcholine, stimulating parasympathetic responses.
  2. 3. The movement of a drug from its site of administration into the bloodstream.
  3. 4. A molecule that binds to a receptor and activates it to produce a biological response.
  4. 6. Drugs that increase urine formation and help reduce blood pressure and edema.
  5. 8. Refers to drugs or receptors related to adrenaline and noradrenaline actions.
  6. 10. Enzyme that plays a key role in the Renin-Angiotensin-Aldosterone pathway controlling blood pressure.
  7. 13. Condition treated with drugs that enhance cardiac output and reduce workload.
  8. 15. Drugs that block the action of acetylcholine in parasympathetic nerves.
  9. 16. Drugs that inhibit calcium ion entry into cardiac and smooth muscle, leading to relaxation.
  10. 18. Specific biological sites, such as enzymes or receptors, that drugs bind to in order to exert their effects.