Across
- 6. reduced drug effect over time requiring higher doses
- 7. benzodiazepine reversal agent
- 8. peripheral dopa-decarboxylase inhibitor; protects levodopa before BBB
- 13. sedative that preserves respiratory drive; used for ICU sedation
- 15. opioid reversal agent
- 16. main excitatory neurotransmitter for learning and memory
- 17. dissociative anesthetic; causes amnesia and increases BP/HR
- 18. potent opioid analgesic for severe pain or anesthesia adjunct
- 20. enzyme inhibitor that increases acetylcholine at synapses
- 23. receptor stimulation relaxes bronchial smooth muscle causing bronchodilation
- 24. neurotransmitter deficient in Parkinson disease
- 25. crisis SLUDGE symptoms from excess acetylcholine
- 29. nervous system “fight or flight” division
- 34. primary parasympathetic neurotransmitter
- 35. stimulation causes vasoconstriction and increases blood pressure
- 36. osmotic diuretic to lower intracranial pressure
- 38. CNS depressant; enhances GABA; risk of respiratory depression
- 40. muscarinic agonist that stimulates urination
- 41. centrally acting antispastic for MS or spinal injury
- 42. short-acting IV benzodiazepine for rapid sedation or seizures
- 43. anticholinergic that reduces Parkinson tremor
- 44. GABA analog for neuropathic pain and partial seizures
Down
- 1. causes fetal malformations; avoid in pregnancy
- 2. side effects dry mouth, blurred vision, constipation, urinary retention
- 3. sedation scale used to assess agitation or sedation depth
- 4. drug class that stabilizes neurons to prevent seizures
- 5. broad-spectrum antiepileptic with few interactions
- 9. antiepileptic; risk of bone marrow suppression and rash
- 10. IV anesthetic; rapid onset, short duration; risk of hypotension
- 11. antiepileptic; notable risk of gingival hyperplasia
- 12. anticholinergic for overactive bladder; causes dry mouth
- 13. long-acting benzodiazepine for anxiety, seizures, muscle spasm
- 14. activation inhibits norepinephrine release (negative feedback)
- 16. main inhibitory neurotransmitter in CNS
- 19. receptor activated by epinephrine and norepinephrine
- 21. increased muscle tone from CNS injury; treated with baclofen
- 22. receptor activated by acetylcholine in smooth muscle and glands
- 26. tissue overgrowth from chronic phenytoin use
- 27. type of seizure risk when antiepileptics are stopped abruptly
- 28. selective barrier limiting CNS drug entry
- 29. depolarizing neuromuscular blocker for rapid intubation
- 30. nervous system “rest and digest” division
- 31. acetylcholinesterase inhibitor for myasthenia gravis
- 32. receptor stimulation increases heart rate and contractility
- 33. dopamine precursor that crosses the BBB for Parkinson disease
- 34. anticholinergic for bradycardia; dries secretions
- 37. primary sympathetic neurotransmitter
- 39. broad antiepileptic; hepatotoxic and teratogenic