Opioids

2. short acting opioid antagonist used for overdose reversal
4. Brand name of extended-release oxycodone
6. Brand name of buprenorphine/naloxone combination
8. prescription antidiarrheal combined with atropine
11. OTC peripheral μ-agonist used for diarrhea
14. Highly potent synthetic opioid; transdermal patch available
15. Brand name for fentanyl transdermal system
16. biased μ-agonist designed to reduce β-arrestin–mediated respiratory depression
17. Gold-standard opioid for severe pain; active metabolite of heroin
19. Partial μ-agonist used in opioid use disorder
20. Prodrug requiring CYP2D6 for conversion to morphine; ineffective in poor metabolizers
22. Weak μ-agonist + SNRI activity; seizure risk
24. Brand name of naloxone nasal spray

1. High-potency synthetic opioid; CYP3A4 substrate; significant overdose risk with inhibitors
3. metabolite that can accumulate and causes seizures
5. OTC antitussive with abuse potential at high doses
7. Semisynthetic opioid commonly combined with acetaminophen
9. for intrathecal administration only
10. opioid with lowest histamine release
12. causes precipitated withdrawal in patients on chronic opioids
13. Long-acting opioid; QT prolongation risk
18. non-opioid allosteric inhibitor of peripheral sodium NaV1.8 channels
21. brand name of opioid that has deadly drug interaction with MAO inhibitors
23. Brand name for hydromorphone