Opioids

4. Semisynthetic opioid commonly combined with acetaminophen
8. metabolite that can accumulate and causes seizures
11. Brand name for fentanyl transdermal system
12. Brand name of naloxone nasal spray
14. Brand name of buprenorphine/naloxone combination
15. High-potency synthetic opioid; CYP3A4 substrate; significant overdose risk with inhibitors
16. brand name of opioid that has deadly drug interaction with MAO inhibitors
18. Partial μ-agonist used in opioid use disorder
21. OTC peripheral μ-agonist used for diarrhea
22. OTC antitussive with abuse potential at high doses

1. non-opioid allosteric inhibitor of peripheral sodium NaV1.8 channels
2. Gold-standard opioid for severe pain; active metabolite of heroin
3. Prodrug requiring CYP2D6 for conversion to morphine; ineffective in poor metabolizers
5. causes precipitated withdrawal in patients on chronic opioids
6. short acting opioid antagonist used for overdose reversal
7. Weak μ-agonist + SNRI activity; seizure risk
9. for intrathecal administration only
10. Highly potent synthetic opioid; transdermal patch available
11. prescription antidiarrheal combined with atropine
13. Brand name of extended-release oxycodone
15. opioid with lowest histamine release
17. Long-acting opioid; QT prolongation risk
19. biased μ-agonist designed to reduce β-arrestin–mediated respiratory depression
20. Brand name for hydromorphone