Across
- 2. Modern framework integrating biology psychology and environment in pain.
- 6. Major ascending pathway carrying pain and temperature.
- 7. Loss of inhibitory control increasing dorsal horn excitability.
- 8. Descending or local alteration of pain signal strength.
- 10. Organization that formally defines pain in modern medicine.
- 11. Fast excitatory receptor mediating early synaptic transmission.
- 17. Increased responsiveness of neurons after injury.
- 18. Endogenous system that inhibits nociceptive transmission.
- 20. Primary excitatory neurotransmitter in pain pathways.
- 21. Primary sensory neuron specialized for detecting tissue damage.
- 22. Brain to spinal cord pathway that can suppress pain.
- 25. Major inhibitory neurotransmitter limiting dorsal horn excitation.
Down
- 1. Pain evoked by a normally nonpainful stimulus.
- 3. Endogenous peptide activating opioid receptors.
- 4. Activity dependent strengthening underlying persistent pain states.
- 5. Relay station directing nociceptive input to cortex.
- 9. Ascending movement of nociceptive signals to the brain.
- 12. Protective short duration pain following injury.
- 13. Receptor central to synaptic plasticity and chronic pain development.
- 14. Pain state persisting beyond normal tissue healing.
- 15. Conversion of noxious stimulus into electrical activity.
- 16. Conscious experience generated after cortical processing.
- 19. Exaggerated response to a normally painful stimulus.
- 23. Site where pain becomes a subjective experience.
- 24. Peripheral biological response that lowers nociceptor threshold.