Across
- 2. inactive precursor of proteolytic enzyme
- 3. inhibitor of NOS
- 5. reduces the bioavailability of nitric oxide
- 7. vascular cell adhesion molecule 1
- 9. product of the mavelonate pathway
- 11. factor II
- 12. describes platelets that have not been activated
- 14. reduces platelet aggregation by inhibiting PDE, blocking adenosine uptake into red cells, and reduces TXA2 synthesis
- 17. inhibits cyclooxygenase
- 18. clotting pathway initiated by tissue damage
- 19. monocyte chemotactic protein 1
- 20. two thirds of the body's cholesterol is synthesised here
- 22. clotting pathway initiated by contact with glass
- 23. activates guanylyl cyclase, which converts GTP to cyclic GMP
Down
- 1. a natural anticoagulant
- 4. substrate for nitric oxide synthase
- 6. maintains platelets inactive state by releasing PGI2 and NO
- 8. cGMP can produce this effect in blood vessels
- 9. the principal matrix protein that interacts with platelets
- 10. P2X antagonist that inhibits ADP-induced platelet aggregation
- 13. converts soluble fibrinogen to insoluble strands of fibrin
- 15. end product of the coagulation pathway
- 16. inhibit the rate-limiting enzyme for cholesterol biosynthesis
- 21. bridging molecule