Across
- 3. inactive precursor of proteolytic enzyme
- 4. inhibit the rate-limiting enzyme for cholesterol biosynthesis
- 7. maintains platelets inactive state by releasing PGI2 and NO
- 9. factor II
- 10. vascular cell adhesion molecule 1
- 13. cGMP can produce this effect in blood vessels
- 15. inhibitor of NOS
- 16. product of the mavelonate pathway
- 18. substrate for nitric oxide synthase
- 19. reduces the bioavailability of nitric oxide
- 20. a natural anticoagulant
- 22. clotting pathway initiated by tissue damage
- 23. end product of the coagulation pathway
Down
- 1. describes platelets that have not been activated
- 2. two thirds of the body's cholesterol is synthesised here
- 5. converts soluble fibrinogen to insoluble strands of fibrin
- 6. reduces platelet aggregation by inhibiting PDE, blocking adenosine uptake into red cells, and reduces TXA2 synthesis
- 8. P2X antagonist that inhibits ADP-induced platelet aggregation
- 11. the principal matrix protein that interacts with platelets
- 12. monocyte chemotactic protein 1
- 13. bridging molecule
- 14. clotting pathway initiated by contact with glass
- 17. inhibits cyclooxygenase
- 21. activates guanylyl cyclase, which converts GTP to cyclic GMP