Across
- 2. Teratogenesis or _______ defect development may be an toxic effect of some drugs
- 4. The study of chemicals on biological systems
- 5. Dose or concentration of drug that is effective
- 6. Interacts with receptor to block the action of an agonist
- 7. Lethal dose and _________ dose are both used in determining a drug's safety margin
- 9. Type of drug administration that would have 100% bioavailability
- 13. Any substance that brings about a change in biological function
- 14. Acronym for determining drug disposition
- 15. Two ways for the body to limit a drug's effect include metabolism and _________
- 16. The organ responsible for the majority of drug metabolism
Down
- 1. Intensity of molecular or cellular change that results from the drug-receptor interaction
- 3. _______ index is intended to indicate the margin of safety of a drug
- 5. This phase is primarily concerned with safety during drug development
- 6. Describes the passage of a drug from its site of administration into the plasma
- 8. The study of adverse effect of chemicals on living organisms
- 10. Drug receptors can be intra- or _______cellular
- 11. Specific macromolecule with which a drug may interact to exert its effects
- 12. Mutual attraction between drug and receptor
- 13. The amount of chemical being administered