Across
- 3. The study of the influence of genetics on drug response
- 7. A fast decrease of the effect caused by the ligand after continuous or repeated drug administration
- 8. A physiological response to a new situation or conflicts that can become a pathological problem if it is too intense or long lasting
- 9. Molecules able to bind to a receptor but not able to trigger any effect
- 10. A chronic disorder characterized by recurrent seizures caused by sudden excessive electrical discharges in a group of neurons
- 12. Type of interaction that modifies the action mechanism of the drug without varying its plasma concentration
- 15. Endogenous opioid mediators that regulate pain, respiration, body temperature, and stress responses
- 17. The science and activities relating to the detection, assessment, understanding and prevention of adverse effects
- 21. An unpleasant sensory and emotional experience associated with actual or potential tissue damage
- 22. An atypical antipsychotic that treats vertigo with low doses and is used as an antipsychotic at high doses
- 23. A functional disturbance due to injuries in motor pathways which leads to severe muscle spasms
- 24. Enzymes that contain an extracellular domain that binds ligands, a transmembrane domain and an intracellular domain involved in phosphorylation reactions
- 25. A drug used as a prophylactic measure for reducing the number of mania or depression crises, which has a narrow therapeutic window
- 26. Process in which the resulting action is greater than the sum of the individual actions because both drugs act on different receptors
Down
- 1. Tendency of a drug, once bound, to activate the receptor and cause a response or maximum effect
- 2. A dopamine precursor used to activate dopamine receptors directly
- 4. A non-competitive antagonist of the NMDA receptors that prevents excitotoxicity
- 5. The fraction of an administered dose of unchanged drug that reaches the systemic circulation
- 6. Any chemical substance that produces changes in living organisms
- 11. A pure antagonist used to combat morphine intoxication and reverse respiratory depression immediately
- 13. A series of cascade reactions triggered by the ligand and receptor interaction that occur in the cytosol and are devoted to amplifying the response
- 14. Effects in the fetus that include any morphological, biochemical or behavioral side effect caused during fetal development
- 16. A mental disorder whose positive symptoms are produced by a dopamine hyperactivity in the mesolimbic and nigrostriatal systems
- 18. A special type of syndrome which mainly affects the emotional state of the patient, rather than disturbances of thought or cognition
- 19. An antagonist used for treating benzodiazepine intoxications by blocking their binding site
- 20. Tendency of a drug to bind to its receptors