Across
- 2. First-order rate constant k governing decline in Cp
- 5. Shape of Cp-versus-time curve after a dose
- 7. PK parameters that are constant within a patient but vary across individuals
- 9. Pharmacokinetic values directly measured: Cl and Vd
- 11. Model assuming immediate distribution throughout Vd
- 14. Time Cp remains above MEC after an IV bolus
- 15. Cp₀ equal to SFD divided by Vd
- 16. Single rapid dose administered at time zero
- 19. Amount of drug in body immediately after IV bolus (SFD)
Down
- 1. Plasma plus rapidly perfused tissues where Cp is measured
- 3. Model-calculated Cp at any future time point
- 4. Values derived from primary parameters: k and t½
- 6. Assumption that entire dose enters body immediately
- 8. Determining Cl, Vd, and k from plasma concentration data
- 10. Time between repeated doses; trough measured at end of tau
- 12. Narrow therapeutic window drugs requiring monitoring (e.g., digoxin)
- 13. IV amount needed to instantly reach a desired Cp₀
- 17. Time required for Cp or amount to fall by 50 percent
- 18. Slope on ln(Cp) vs time plot used to compute k