Reactive Oxygen Species (ROS)

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Across
  1. 3. A harmful effect of ROS on the cell is damage of ____.
  2. 4. Breaks the covalent links that ROS forms between fatty acid side chains in membrane lipids.
  3. 8. ROS are produced as a normal product of __________ _____________.
  4. 9. ROS have an important role in _______ or cell death.
  5. 10. A cancer cell can die in three ways: apoptosis, _____________, and autophagy.
  6. 12. Both exogenous and endogenous ROS have been shown to enhance __________ of cancer cells.
  7. 13. Reactive oxygen species are chemically reactive molecules containing _______.
  8. 14. ____________ cells exhibit greater ROS stress than normal cells.
  9. 16. ROS can trigger activation of ____________ pathways.
  10. 17. _________ ROS can be produced from pollutants, drugs or radiation.
  11. 19. ROS can promote _________ cell proliferation.
  12. 20. ROS levels increase dramatically during times of environmental __________.
Down
  1. 1. ROS can also recruit additional ______ to sites of injury to promote clotting.
  2. 2. ROS is considered the major contributor of ________.
  3. 5. The most reactive ROS.
  4. 6. ROS-related oxidation of DNA is one of the main causes of ______________.
  5. 7. ROS are a natural byproduct of the _______ of oxygen.
  6. 11. High levels of ROS may result in damage to cell _________.
  7. 15. Cells defend themselves against ROS damage with __________.
  8. 18. Most chemotherapeutic agents kill cancer cells by augmenting ROS ________.