Across
- 2. Rapid loss of response to a drug such as ephedrine after repeated doses
- 7. Oral alpha agonist for orthostatic hypotension; lasts 2–3 hours
- 9. Refers to the strength of myocardial contraction
- 10. Indirect sympathomimetic that releases norepinephrine; subject to tachyphylaxis
- 11. Enzyme inhibited by milrinone and amrinone to increase cAMP
- 13. Balanced catecholamine and mast cell stabilizer; first choice for anaphylaxis
- 14. Drug that stimulates alpha-adrenergic receptors causing vasoconstriction
- 20. Chemical messenger released by neurons to transmit signals across synapses
- 22. Condition treated with hydroxocobalamin via nitric oxide scavenging
- 24. Non-sympathomimetic vasopressor; “new vasopressin” with potent vasoconstriction
- 25. Calcium sensitizer that stabilizes troponin-Ca2+ binding without increasing Ca2+ affinity
- 26. Class of endogenous compounds including dopamine, norepi, and epi
- 27. Vascular region dilated by low-dose dopamine
Down
- 1. Narrowing of blood vessels; increases systemic vascular resistance
- 3. Oral calcium sensitizer used to treat congestive heart failure
- 4. PDE3 inhibitor that increases cAMP and Ca2+ to improve inotropy; hepatic excretion
- 5. Blocks guanylate cyclase to reverse refractory vasodilation; rescue agent for MAP<50
- 6. Non-sympathomimetic vasopressor acting via V1, V2, and V3 receptors
- 8. Endogenous catecholamine with potent alpha effects and little change in cardiac output
- 12. Direct alpha agonist similar to phenylephrine but longer acting
- 15. Older PDE3 inhibitor that increases contractility by increasing cAMP
- 16. Synthetic catecholamine with B1>B2 (3:1) activity; increases myocardial oxygen consumption
- 17. Precursor catecholamine that activates D1/D2 receptors at low doses; indirect acting “dumb drug”
- 18. Direct alpha agonist with rapid onset and short duration
- 19. Drug that stimulates beta-adrenergic receptors to increase heart rate and contractility
- 21. Also known as Cyanokit; nitric oxide scavenger and cyanide antidote
- 23. Potent nonselective beta agonist (B1=B2); no alpha effect causing vasodilation