Across
- 3. Genes that mediate cellular signal transduction pathways that promote cell growth, proliferation, and differentiation.
- 7. Gamma herpesvirus causative agent of Burkitt’s lymphoma,Hodgkin’s Disease, and Nasopharyngeal carcinoma.
- 9. Tumor suppressor protein that senses DNA damage, unscheduled DNA synthesis, and promotes apoptosis.
- 10. Viral proteins expressed in transformed cells.
- 12. Step that can trigger oncogenesis.
- 14. A series of steps that allows a cell to grow and divide.
- 15. Host oncogenes acquired by retroviruses that can lead to transformation and oncogenesis once mutated.
- 16. Avian Rous Sarcoma Virus characterized by rapid tumor formation.
Down
- 1. Causative agent of adult T cell leukemia.
- 2. Insertion of viral promoter (LTR) activates the expression of endogenous oncogenes
- 4. Causative agent of Kaposi Sarcoma.
- 5. Process that allows P53 tumor suppressor protein to be degraded.
- 6. Cells that can undergo viral transformation in vitro characterized by expression of viral T antigens and integration of viral genomes.
- 8. Tumor suppressor protein that is responsible to control transition from G1 to S in the cell cycle.
- 11. Causative agent of cervical cancer.
- 13. Requires the accumulation of mutations in oncogenes and in tumor suppressor genes